Obesity remains an extremely serious problem worldwide. Once considered a problem for wealthier countries, overweight and obesity are now increasing dramatically in low- and middle-income countries (WHO, 2011). In America, obesity rates continue to rise. The CDC (2009) recognizes obesity as a risk factor for diabetes, heart disease, hypertension, and other health problems. According to NHANES, over two-thirds of Americans are overweight or obese, and over one-third are obese (CDC, 2009). Treatment for this disease varies; may include the integration of diet, exercise, behavior modification, medications, and surgery. Because there is no single cause of overweight and obesity, there is no single way to prevent or treat overweight and obesity that will help everyone (CDC, 2009). African American women have the highest rates of obesity in the country (Gaston et al. al., 2011). Not only are there prevalent disparities between African American and Caucasian women, research has found a disparity between African American men and women (Ogden, 2009). African American women have the highest prevalence of major risk factors – physical inactivity, poor nutrition, and stress – that contribute to poor health outcomes (Gaston, 2011). Understanding the causes of this disparity will help develop interventions targeted to the African-American population for weight loss (Ogden, 2009). This study focuses on obesity in African American women and the impact of faith-based interventions on weight loss. Methodology This is a faith-based weight loss study, based on a randomized control, pre-test and post-test design, with interventions aimed at addressing obesity in African-American women. This drawing measured before the middle of the sheet of paper, eating habits, walking and exercise. This program allowed the researcher to teach a weight management class and a week of skills. All topics support the messages provided in the Dietary Guidelines for Americans and My Pyramid. The intervention group met after the weight loss education group. This faith-based series developed by the researcher consisted of 30 minutes. This group discussed the scriptures, the importance of prayer, journaling success, and the exercise commission. Summary African Americans continue to lead the nation with the highest rates of overweight and obesity. Healthy People 2010 established nationwide obesity reduction goals. The research supports the identification of cultural interventions specific to this target population. The focus of this study was faith intervention as a tool to support increased weight loss in African Americans.