Extensive research has been conducted as a macromolecular carrier for protein or drug delivery for biomedical medicine application. Based on its architecture, the hydroxyl groups attached to the main chain of dextran make it possible to undergo oxidation with periodate to provide an entry composed of multiple aldehyde groups, which serves as a polymer cross-linker for polymers containing free amino groups to form the hydrogel . Therefore,. Gelatin hydrogel is characterized by rapid solubilization in an aqueous environment and dissolves easily in the body temperature range, thus limiting its potential in the biomedical area